The living organoid biobank created by HUB and its partners consists of more than 1000 organoid cultures representing a variety of organs and disease models. For monogenetic diseases, the HUB living organoid biobank includes intestinal and lung organoids from Cystic Fibrosis patients and liver organoids from patients with metabolic diseases (e.g. alpha-1 antitrypsin, Crigler-Najjar, etc.). The HUB living organoid biobank also has an important representation of cancer models including breast, colorectal, head and neck, intestinal, liver, lung, ovarian, pancreatic tumour organoids. For some of these cancer models, organoids derived from normal (cancer-free) adjacent tissue are also available.
Using the living organoid biobank, HUB explores novel therapeutic strategies, including responsiveness to drug combinations to develop rules for patient stratification based on drug sensitivity in vitro. Connecting genomic heterogeneity and gene function to in vitro drug responsiveness will lead to the development of a road map for improved treatment strategies.