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HUB Organoids have advanced many areas of research, including the study of infectious diseases. Most recently HUB Organoids have become a clinical tool to understand the infectivity and mechanistic study of SARS-CoV-2. Have a read of this Technology Networks article we co-authored with Corning Life Sciences.

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The European-funded Human Individualized Treatment for Cystic Fibrosis (HIT-CF) project is using HUB Organoid Technology to match patients to drugs that will be effective for CF caused by rare mutations. First, by screening patient-derived organoids in the lab, then in personalized clinical trials based on lab results.

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In this study, Vertex Pharmaceuticals used organoids as a complementary in vitro model to characterize cryptic splice mutations that cannot be assessed fully in recombinant cell systems expressing cDNA constructs.